![]() ![]() There have been reports of some life-threatening complications associated with ZLP overdose, such as suicidal attempts, seizure, and coma ( 13, 14). ZLP as a very commonly prescribed Z-drug has the potential for both medical misuse -when it is taken for the long term without or against medical advice- and recreational use -when is abused to achieve a “high”- ( 11- 13). They woke up easily at eight in the morning after however, they were feeling dizziness, headache, lightheadedness, and gastrointestinal discomfort.ĭue to the tolerance, dependence, and associated adverse effects, the abuse of benzodiazepines and Z-drugs has become a serious public health problem ( 10, 11). Their pupils started to contract as the host flashed the torch into their eyes. Both of them reacted to loud voice and had movement on the bed during their sleep. The host checked their pulse rate and their blood pressure with an automatic sphygmomanometer and they were normal. After a short time, they fell asleep fast while breathing normally. ![]() They were advised to go to sleep by the host. He stated, “I did not want to seem suspicious”.Īfter returning to the house, case 1 and case 2 attempted to use 60 mg of ZLP apiece. Case 1 entered the pharmacy and bought a full package of ZLP 10 mg with a package of atorvastatin 10 mg tablets. Case 2 said that some people were hiding behind the trees and were watching them. Along the way, both cases 1 and 2 were unable to navigate the pathway to the pharmacy and their balance was impaired. He joined them towards a 24-hour pharmacy in case any unexpected problem occurred. The host tried his best to prevent them from going out, but they remained utterly determined. He got prepared for buying ZLP and case 2 decided to accompany him. The first case demanded some more ZLP tablets. In the middle of the dinner, the second case started to fancy that several people with deformed faces and winding bodies were gazing through the room window. He just drank a lot of water and talked about a mixture of religious, romantic, and philosophical topics. Case 1 started eating food voraciously and non-stop while opining around music for about 30 minutes. After a few minutes, they were invited to a dining room to have the meal. ![]() Unbeknown to the host, as they arrived at his house, they each took four pills of ZLP 5 mg with a full glass of water. He was free of any other medication.Īs both cases declared later, they suffered a dramatically gloomy night on 3rd November 2016. Within the recent 2 years, he had been taking 10-80 mg of ZLP on an irregular basis and he had entirely forgotten the happenings of the nights when he took ZLP.Ĭase 2: He had only used ZLP for a few times and he did not have any history of continuous use of this drug. He also had a history of an unsuccessful suicide attempt upon taking ZLP. He used to use ZLP for his sleeping problems, but in the repercussion of repetitive use, he became interested in the pleasurable and felicific mental encounters of ZLP. He had not any history of using another drug. Two 29-year-old single males who were graduated in pharmacy, sharing an apartment in Tehran, without any diagnosed mood disorder or neuropsychiatric disease, went to another pharmacist friend’s house to have dinner together.īeing fully alert and free of any drug at that night, the host declared the following statements:Ĭase 1: He had been using ZLP often but irregularly throughout the past 2 years. It merits mentioning that a larger number of these cases had used ZLP more than the prescribed dose and most of these people had a history of substance or drug abuse and/or psychiatric disorders ( 6, 9).įurther to the extant reports of adverse reactions related to zolpidem use, hereby two cases with zolpidem intoxication effects are presented. Although ZLP appears to be well tolerated in adults ( 8), there are so many reports of abuse, dependence, and withdrawal syndrome of ZLP. Several systematic descriptive reviews of ZLP dangerous side effects including psychotic types have been undertaken ( 6, 7). Nausea, dizziness, malaise, hallucination, nightmares, agitation, and headache are some of the most frequently reported adverse effects of ZLP ( 5). Side effects related to ZLP have been frequently reported. It has attained popularity as an alternative to benzodiazepines due to the claims regarding its milder and fewer problematic side effects although they have been refuted in recent studies ( 2- 4). The Z-drug zolpidem (ZLP) is an imidazopyridine hypnotic that is prescribed widely for short-term treatment of sleeping problems ( 1). ![]() Zolpidem use may affect the mental status and results in performing unconscious behaviors.Īltered Mental Status Case Report Insomnia Somnambulism Zolpidem 1. ![]()
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